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Ozempic dosing: every step on the FDA label, and what each dose costs

Ozempic injection

Starting dose

  • Start 0.25 mg weekly for 4 weeks. Initiate OZEMPIC with a dosage of 0.25 mg injected subcutaneously once weekly for 4 weeks.dailymed.nlm.nih.gov, Sep 27, 2026

Stepping up

  • After 4 weeks go to 0.5 mg. After 4 weeks on the 0.25 mg dosage, increase the dosage to 0.5 mg once weekly.dailymed.nlm.nih.gov, Sep 27, 2026
  • If additional glycemic control is needed after at least 4 weeks on the: dailymed.nlm.nih.gov, Sep 27, 2026
  • 0.5 mg to 1 mg. 0.5 mg dosage, the dosage may be increased to 1 mg once weekly.dailymed.nlm.nih.gov, Sep 27, 2026
  • 1 mg to 2 mg. 1 mg dosage, the dosage may be increased to 2 mg once weekly.dailymed.nlm.nih.gov, Sep 27, 2026

Maintenance and maximum dose

  • Maintenance 0.5, 1 or 2 mg weekly based on glycemic control. The recommended maintenance dosage is 0.5 mg, 1 mg, or 2 mg, injected subcutaneously once weekly, based on glycemic control.dailymed.nlm.nih.gov, Sep 27, 2026
  • Maximum 2 mg weekly. The maximum recommended dosage is 2 mg once weekly.dailymed.nlm.nih.gov, Sep 27, 2026
  • Type 2 diabetes with CKD: maintenance 1 mg weekly. Increase the dosage to the maintenance dosage, 1 mg once weekly, after at least 4 weeks on the 0.5 mg dosage.dailymed.nlm.nih.gov, Sep 27, 2026

If you miss a dose

  • Missed dose: take within 5 days; otherwise skip and resume. If a dose is missed, administer OZEMPIC as soon as possible within 5 days after the missed dose. If more than 5 days have passed, skip the missed dose and administer the next dose on the regularly scheduled day. In each case, patients can then resume their regular once-weekly dosing schedule.dailymed.nlm.nih.gov, Sep 27, 2026
  • Dosing day can change if doses are at least 2 days (>48 h) apart. The day of weekly administration can be changed if necessary as long as the time between two doses is at least 2 days (>48 hours).dailymed.nlm.nih.gov, Sep 27, 2026

How it comes

  • Multi-dose pens: doses per pen. Injection: 2 mg/3 mL (0.68 mg/mL) for 4 doses of 0.25 mg and 2 doses of 0.5 mg or 4 doses of 0.5 mg, 4 mg/3 mL (1.34 mg/mL) for 4 doses of 1 mg, and 8 mg/3 mL (2.68 mg/mL) for 4 doses of 2 mg in single-patient-use pens (3)dailymed.nlm.nih.gov, Sep 27, 2026
  • Single-dose prefilled syringes. Injection: 0.25 mg, 0.5 mg or 1 mg per 0.5 mL in a single-dose prefilled syringe (3)dailymed.nlm.nih.gov, Sep 27, 2026
  • 0.25/0.5 mg starter pen row (NDC). 0.25 mg 0.5 mg Initiation Maintenance 2 mg/3 mL 4 doses of 0.25 mg and 2 doses of 0.5 mg or 4 doses of 0.5 mg 1 pen 6 NovoFine® Plus needles 0169-4181-13dailymed.nlm.nih.gov, Sep 27, 2026
  • 1 mg pen row (NDC). 1 mg Maintenance 4 mg/3 mL 4 doses of 1 mg 1 pen 4 NovoFine® Plus needles 0169-4130-13dailymed.nlm.nih.gov, Sep 27, 2026
  • 2 mg pen row (NDC). 2 mg Maintenance 8 mg/3 mL 4 doses of 2 mg 1 pen 4 NovoFine® Plus needles 0169-4772-12dailymed.nlm.nih.gov, Sep 27, 2026
  • 0.25 mg single-dose prefilled syringe: carton of 4 (NDC). 0.25 mg Initiation 0.25 mg / 0.5 mL Single-dose 4 Prefilled Syringes 0169-1302-14dailymed.nlm.nih.gov, Sep 27, 2026
  • 0.5 mg single-dose prefilled syringe: carton of 4 (NDC). 0.5 mg Maintenance 0.5 mg / 0.5 mL Single-dose 4 Prefilled Syringes 0169-1305-14dailymed.nlm.nih.gov, Sep 27, 2026
  • 1 mg single-dose prefilled syringe: carton of 4 (NDC). 1 mg Maintenance 1 mg / 0.5 mL Single-dose 4 Prefilled Syringes 0169-1310-14dailymed.nlm.nih.gov, Sep 27, 2026

Label revised 5/2026: full label on DailyMed.

Ozempic tablets

Starting dose

  • OZEMPIC tablets start 1.5 mg daily for days 1-30 (not effective for glycemic control). Starting Dosage (Initiation Phase) (Days 1 through 30): The recommended starting dosage is 1.5 mg orally once daily (this dosage is not effective for glycemic control).dailymed.nlm.nih.gov, Sep 27, 2026

Stepping up

  • Days 31-60: 4 mg daily. Days 31 to 60: Increase the dosage to 4 mg orally once daily.dailymed.nlm.nih.gov, Sep 27, 2026
  • From day 61, increase to 9 mg if more glycemic control needed. Additional glycemic control is needed, increase the dosage to 9 mg orally once daily.dailymed.nlm.nih.gov, Sep 27, 2026

Maintenance and maximum dose

  • From day 61, stay at 4 mg daily if no more glycemic control is needed. No additional glycemic control is needed, maintain the dosage at 4 mg orally once daily.dailymed.nlm.nih.gov, Sep 27, 2026

If you miss a dose

  • Missed tablet: skip it and take the next dose the following day. If a dose is missed, skip the missed dose and take the next dose the following day.dailymed.nlm.nih.gov, Sep 27, 2026

Switching between forms

  • RYBELSUS and OZEMPIC tablets are not mg-for-mg interchangeable. RYBELSUS and OZEMPIC tablets are not substitutable on a mg-to-mg basis.dailymed.nlm.nih.gov, Sep 27, 2026
  • No switching between the two tablet products during days 1-30. Do not switch between RYBELSUS and OZEMPIC tablets during the initiation phase (Days 1 to 30) [see Dosage and Administration (2.2)].dailymed.nlm.nih.gov, Sep 27, 2026
  • Switch by starting the other tablet product the next day. When switching between RYBELSUS and OZEMPIC tablets, initiate the other semaglutide tablet product the day after discontinuing the previous semaglutide tablet product.dailymed.nlm.nih.gov, Sep 27, 2026
  • Equivalent doses: RYBELSUS 7 mg = OZEMPIC tablets 4 mg. 7 mg orally once daily 4 mg orally once dailydailymed.nlm.nih.gov, Sep 27, 2026
  • Equivalent doses: RYBELSUS 14 mg = OZEMPIC tablets 9 mg. 14 mg orally once daily 9 mg orally once dailydailymed.nlm.nih.gov, Sep 27, 2026
  • Injection to tablets allowed from Ozempic 0.5 mg injection. Patients taking the 0.5 mg dose of OZEMPIC injection may switch to OZEMPIC tablets.dailymed.nlm.nih.gov, Sep 27, 2026
  • Start 4 or 9 mg tablets one week after the last 0.5 mg injection. One week after discontinuing 0.5 mg of subcutaneous OZEMPIC injection, start 4 mg or 9 mg of OZEMPIC tablets orally once daily.dailymed.nlm.nih.gov, Sep 27, 2026

How it comes

  • OZEMPIC tablet strengths. OZEMPIC tablets: 1.5 mg, 4 mg and 9 mg (3)dailymed.nlm.nih.gov, Sep 27, 2026
  • 1.5 mg: bottle of 30 tablets (NDC). 1.5 mg White to light yellow, round shaped debossed with “1.5” on one side and “novo” on the other side Bottle of 30 tablets 0169-1715-30dailymed.nlm.nih.gov, Sep 27, 2026
  • 4 mg: bottle of 30 tablets (NDC). 4 mg White to light yellow, round shaped debossed with “4” on one side and “novo” on the other side Bottle of 30 tablets 0169-1704-30dailymed.nlm.nih.gov, Sep 27, 2026
  • 9 mg: bottle of 30 tablets (NDC). 9 mg White to light yellow, round shaped debossed with “9” on one side and “novo” on the other side Bottle of 30 tablets 0169-1709-30dailymed.nlm.nih.gov, Sep 27, 2026

Label revised 1/2026: full label on DailyMed.

What each dose costs, self-pay

Injection, pen from NovoCare Pharmacy

Pill from NovoCare Pharmacy

52-week totals and every place to buy it: Ozempic cost.

Your prescriber decides your dose; this page reports the label. Medical disclaimer.