GLP-1 side effects compared
How often each common side effect was reported at the highest dose in each medication's own label table, with that trial's placebo rate in brackets. Each column comes from a different trial with different people, so this is not a head-to-head comparison.
| Side effect | Zepbound injection, 15 mg | Wegovy injection, 2.4 mg | Foundayo tablets, 17.2 mg | Ozempic injection, 1 mg | Ozempic tablets, semaglutide tablets 14 mg (Rybelsus trials) | Mounjaro injection, 15 mg |
|---|---|---|---|---|---|---|
| Nausea | 28% (8%) | 44% (16%) | 35% (10%) | 20.3% (6.1%) | 20% (6%) | 18% (4%) |
| Diarrhea | 23% (8%) | 30% (16%) | 25% (11%) | 8.8% (1.9%) | 10% (4%) | 17% (9%) |
| Vomiting | 13% (2%) | 24% (6%) | 24% (4%) | 9.2% (2.3%) | 8% (3%) | 9% (2%) |
| Constipation | 11% (5%) | 24% (11%) | 24% (9%) | 3.1% (1.5%) | 5% (2%) | 7% (1%) |
| Abdominal Pain | 10% (5%) | 20% (10%) | 14% (7%) | 5.7% (4.6%) | 11% (4%) | 5% (4%) |
| Dyspepsia | 10% (4%) | 9% (3%) | 13% (4%) | Not in the table | Not in the table | 5% (3%) |
| Fatigue | 7% (3%) | 11% (5%) | 9% (4%) | Not in the table | Not in the table | Not in the table |
| Headache | Not in the table | 14% (10%) | 9% (7%) | Not in the table | Not in the table | Not in the table |
| Dizziness | 4% (2%) | 8% (4%) | Not in the table | Not in the table | Not in the table | Not in the table |
| Eructation | 5% (1%) | 7% (<1%) | 8% (1%) | Not in the table | Not in the table | Not in the table |
| Hair Loss | 5% (1%) | 3% (1%) | 5% (2%) | Not in the table | Not in the table | Not in the table |
"Not in the table" means that reaction is not a row in the label's main table (some labels mention it in the text instead; see each medication's page). Ozempic and Mounjaro rates come from type 2 diabetes trials, the others from weight-management trials.
- Zepbound side effects
- Wegovy side effects
- Foundayo side effects
- Ozempic side effects
- Ozempic side effects
- Mounjaro side effects
This page reports the labels; it is not medical advice. Medical disclaimer.